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Structural and Biophysical Insights into the TCRαβ Complex in Chickens

Summary: In this work, chicken HPAIV H5N1 epitope-specific TCRαβ (ch-TCRαβ) was isolated and its structure was determined. The Cα domain of ch-TCRαβ does not exhibit the typical structure of human TCRαβ, and the DE loop extends outward, resulting in close proximity between the Cα domain of ch-TCRαβ...

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Autors principals: Lijie Zhang, Yanjie Liu, Geng Meng, Ruiying Liang, Bing Zhang, Chun Xia
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020-12-01
Col·lecció:iScience
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2589004220310257
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