Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity

Abstract Background Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer, and KRAS oncogene occurs in over 90% of cases. P21-activated kinases (PAK), containing six members (PAK1 to 6), function downstream of KRAS. PAK1 and PAK4 play important roles in carcinogenesis, but...

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Ngā kaituhi matua:	Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2024-05-01
Rangatū:	Cell Communication and Signaling
Ngā marau:	P21-activated kinases1&4 Intra-tumoral T cells Pancreatic ductal adenocarcinoma
Urunga tuihono:	https://doi.org/10.1186/s12964-024-01670-2
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!