Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity

Abstract Background Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer, and KRAS oncogene occurs in over 90% of cases. P21-activated kinases (PAK), containing six members (PAK1 to 6), function downstream of KRAS. PAK1 and PAK4 play important roles in carcinogenesis, but...

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Autores principales:	Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2024-05-01
Colección:	Cell Communication and Signaling
Materias:	P21-activated kinases1&4 Intra-tumoral T cells Pancreatic ductal adenocarcinoma
Acceso en línea:	https://doi.org/10.1186/s12964-024-01670-2
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