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Predicting T cell receptor functionality against mutant epitopes

Summary: Cancer cells and pathogens can evade T cell receptors (TCRs) via mutations in immunogenic epitopes. TCR cross-reactivity (i.e., recognition of multiple epitopes with sequence similarities) can counteract such escape but may cause severe side effects in cell-based immunotherapies through tar...

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Autori principali: Felix Drost, Emilio Dorigatti, Adrian Straub, Philipp Hilgendorf, Karolin I. Wagner, Kersten Heyer, Marta López Montes, Bernd Bischl, Dirk H. Busch, Kilian Schober, Benjamin Schubert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-09-01
Serie:Cell Genomics
Soggetti:
T cell receptor
epitope
TCR-epitope prediction
cross-reactivity
mutation
deep mutational scan
Accesso online:http://www.sciencedirect.com/science/article/pii/S2666979X24002386
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