Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma

Cancer immunotherapy has made unprecedented breakthrough in the fields of chimeric antigen receptor-redirected T (CAR T) cell therapy and immune modulation. Combination of CAR modification and the disruption of endogenous inhibitory immune checkpoints on T cells represent a promising immunotherapeut...

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Detalhes bibliográficos

Principais autores:	Xingliang Guo, Hua Jiang, Bizhi Shi, Min Zhou, Honghong Zhang, Zhimin Shi, Guoxiu Du, Hong Luo, Xiuqi Wu, Yi Wang, Ruixin Sun, Zonghai Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-10-01
coleção:	Frontiers in Pharmacology
Assuntos:	hepatocellular carcinoma immunotherapy chimeric antigen receptor PD-1 gene editing CRISPR-Cas9
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2018.01118/full
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