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Investigation of the toxicological effects of PFAS on cholangiocarcinoma based on network toxicology, bioinformatics, and molecular docking

Abstract Previous studies have identified an association between per- and polyfluoroalkyl substances (PFAS) and the occurrence of intrahepatic cholangiocarcinoma (ICC), but the specific mechanisms remain unclear. This study aims to analyze the toxicological mechanisms of PFAS, particularly perfluoro...

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Principais autores: Huazheng Sun, Jian Li, Changpu Du, Kangmin Zhou, Zhenzhen Wu, Jia Deng, Guo Chen, Ailing Liang, Bing Yang, Dongxin Tang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-10-01
coleção:Scientific Reports
Assuntos:
PFOA
PFOS
Cholangiocarcinoma
Network toxicology
Bioinformatics
Acesso em linha:https://doi.org/10.1038/s41598-025-19590-7
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