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Investigation of the toxicological effects of PFAS on cholangiocarcinoma based on network toxicology, bioinformatics, and molecular docking

Abstract Previous studies have identified an association between per- and polyfluoroalkyl substances (PFAS) and the occurrence of intrahepatic cholangiocarcinoma (ICC), but the specific mechanisms remain unclear. This study aims to analyze the toxicological mechanisms of PFAS, particularly perfluoro...

Täydet tiedot

Tallennettuna:
Päätekijät: Huazheng Sun, Jian Li, Changpu Du, Kangmin Zhou, Zhenzhen Wu, Jia Deng, Guo Chen, Ailing Liang, Bing Yang, Dongxin Tang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2025-10-01
Sarja:Scientific Reports
Aiheet:
PFOA
PFOS
Cholangiocarcinoma
Network toxicology
Bioinformatics
Linkit:https://doi.org/10.1038/s41598-025-19590-7
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