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Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated from human-skin-cell-derived induced pluripot...

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Principais autores: Kirstin O. McDonald, Nikita M. A. Lyons, Luca K. C. Gray, Janet B. Xu, Lucia Schoderboeck, Stephanie M. Hughes, Indranil Basak
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2024-06-01
Serija:Cells
Teme:
human-induced pluripotent stem cells
dopaminergic neurons
transcription factors
ASCL1
LMX1A
NURR1
Online dostop:https://www.mdpi.com/2073-4409/13/12/1016
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