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Rad23b exacerbates pathological aggregates through disrupting proteasome functions in Spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia globally, caused by expanded CAG repeats in the ATXN3 gene and consequent pathogenic accumulation of mutant ATXN3 (mATXN3) aggregates. The formation of these aggregates perturbs neuronal functions and leads to progress...

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Principais autores: Yi-Ching Chen, Chih-Wei Tung, Siew Chin Chan, Po-Ming Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2026-04-01
סדרה:Neurotherapeutics
נושאים:
Spinocerebellar ataxia type 3 (SCA3)
ATXN3 gene
RAD23 homolog B (Rad23b)
Ubiquitination
Proteasome
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S187874792600098X
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