Rad23b exacerbates pathological aggregates through disrupting proteasome functions in Spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia globally, caused by expanded CAG repeats in the ATXN3 gene and consequent pathogenic accumulation of mutant ATXN3 (mATXN3) aggregates. The formation of these aggregates perturbs neuronal functions and leads to progress...

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Главные авторы:	Yi-Ching Chen, Chih-Wei Tung, Siew Chin Chan, Po-Ming Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2026-04-01
Серии:	Neurotherapeutics
Предметы:	Spinocerebellar ataxia type 3 (SCA3) ATXN3 gene RAD23 homolog B (Rad23b) Ubiquitination Proteasome
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S187874792600098X
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