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Synthesis and Biological Evaluation of New Dihydrofuro[3,2-<i>b</i>]piperidine Derivatives as Potent <i>α</i>-Glucosidase Inhibitors

Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-<i>b</i>]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds <b>32</b> (IC<sub>50</sub> = 0.07 μM) and <b>28</b>...

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Principais autores: Haibo Wang, Xiaojiang Huang, Yang Pan, Guoqing Zhang, Senling Tang, Huawu Shao, Wei Jiao
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2024-03-01
סדרה:Molecules
נושאים:
dihydrofuro[3,2-<i>b</i>]piperidine
iminosugar
<i>C</i>-glycosides
glucosidase
inhibitors
גישה מקוונת:https://www.mdpi.com/1420-3049/29/5/1179
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