Synthesis and Biological Evaluation of New Dihydrofuro[3,2-<i>b</i>]piperidine Derivatives as Potent <i>α</i>-Glucosidase Inhibitors

Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-<i>b</i>]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds <b>32</b> (IC₅₀ = 0.07 μM) and <b>28</b>...

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Autors principals:	Haibo Wang, Xiaojiang Huang, Yang Pan, Guoqing Zhang, Senling Tang, Huawu Shao, Wei Jiao
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-03-01
Col·lecció:	Molecules
Matèries:	dihydrofuro[3,2-<i>b</i>]piperidine iminosugar <i>C</i>-glycosides glucosidase inhibitors
Accés en línia:	https://www.mdpi.com/1420-3049/29/5/1179
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