Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Summary: Interferon γ (IFN-γ) is a key cytokine in immune activation, especially anti-viral responses, and a driver of macrophage activation. It classically signals via JAK1/2-mediated STAT1 homodimers. Here, we identify an alternative, non-canonical signaling component in which IFN-γ simultaneously...

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Principais autores:	Mees Botman, Josje M.A. Huisman, Alexandra Drakaki, Sanne L. Maas, Agnieszka Witalisz-Siepracka, Dagmar Stoiber, Emiel P.C. van der Vorst, Ricky Siebeler, Marten A. Hoeksema
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-02-01
Series:	Cell Reports
Assuntos:	CP: immunology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S221112472600063X
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