The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs12459419T), is unknown. Here, we test wheth...

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Egile Nagusiak:	Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2021-03-01
Saila:	Molecular Neurodegeneration
Gaiak:	Alzheimer’s disease CD33 Immunomodulatory Isoform Microglia Phagocytosis
Sarrera elektronikoa:	https://doi.org/10.1186/s13024-021-00443-6
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