Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts

Niemann-Pick type C (NPC) fibroblasts present a large concentration of cholesterol in their cytoplasm due to a still unidentified deficiency in cholesterol metabolism. The influence of dimethylsulfoxide (DMSO) on the amount of intracellular cholesterol was measured in 8 cultures of normal fibroblast...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	F.B. Scalco, R. Giugliani, P. Tobo, J.C. Coelho
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Associação Brasileira de Divulgação Científica 1999-01-01
Schriftenreihe:	Brazilian Journal of Medical and Biological Research
Schlagworte:	cholesterol metabolism sphingomyelinase Niemann-Pick disease lysosomal storage disorders
Online-Zugang:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100003
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