Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.1 demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
Sábháilte in:
| Príomhchruthaitheoirí: | , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
Elsevier
2021-04-01
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| Sraith: | Cell Reports Medicine |
| Rochtain ar líne: | http://www.sciencedirect.com/science/article/pii/S2666379121000604 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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