MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory endodomains, and we explored whether MyD88 and CD40 (MC) costimulatory endodomains in CARs could improve their antitu...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical investigation
2020-11-01
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| Schriftenreihe: | JCI Insight |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1172/jci.insight.136093 |
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