Myristoyl’s dual role in allosterically regulating and localizing Abl kinase
c-Abl kinase, a key signaling hub in many biological processes ranging from cell development to proliferation, is tightly regulated by two inhibitory Src homology domains. An N-terminal myristoyl modification can bind to a hydrophobic pocket in the kinase C-lobe, which stabilizes the autoinhibitory...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
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eLife Sciences Publications Ltd
2023-10-01
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| Schriftenreihe: | eLife |
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| Online-Zugang: | https://elifesciences.org/articles/85216 |
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