The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes

ABSTRACT Epigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the st...

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Principais autores:	Jesse H. Arbuckle, Andy A. Yanez, Syeda S. Baksh, Tovah E. Markowitz, Jodi L. Vogel, Alison A. McBride, Thomas M. Kristie
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2025-12-01
Series:	Journal of Virology
Assuntos:	SETD8 KMT5A H4K20me1 chromatin accessibility epigenetic regulation herpesvirus
Acceso en liña:	https://journals.asm.org/doi/10.1128/jvi.01293-25
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