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Inhibition of the Super Elongation Complex Suppresses Herpes Simplex Virus Immediate Early Gene Expression, Lytic Infection, and Reactivation from Latency

ABSTRACT Induction of herpes simplex virus (HSV) immediate early (IE) gene transcription promotes the initiation of lytic infection and reactivation from latency in sensory neurons. IE genes are transcribed by the cellular RNA polymerase II (RNAPII) and regulated by multiple transcription factors an...

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Principais autores: Roberto Alfonso-Dunn, Jesse H. Arbuckle, Jodi L. Vogel, Thomas M. Kristie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020-06-01
Serier:mBio
Fag:
transcription elongation
HSV reactivation
HCF-1
AFF4
herpes simplex virus
latency
Online adgang:https://journals.asm.org/doi/10.1128/mBio.01216-20
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