Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
Inhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis. Presenilins (PS) are the catalytic components of γ-secretase complexes that mediate intramembrane proteolysis. Mutations in the PS genes are a major cause of familial early-onset Alzheime...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Life Science Alliance LLC
2020-06-01
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| Серии: | Life Science Alliance |
| Online-ссылка: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201900521 |
| Метки: |
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