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TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome

IntroductionGestational diabetes mellitus (GDM), a common complication of pregnancy, is risky for both mother and fetus. Previous studies about TP53-induced glycolysis and apoptosis regulator (TIGAR) focused on the occurrence and development of cancer, cardiovascular disease, and neurological diseas...

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Autori principali: Junjun Guo, Meijuan Zhou, Man Zhao, Shuxian Li, Zhenya Fang, Anna Li, Meihua Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-04-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114620/full
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