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Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored. Hepatocyte-specific deletion of LRH-1 causes mild steatosis and inflammation but unexpected...

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Principais autores: Rebekka Lambrecht, M. Eugenia Delgado, Vincent Gloe, Karina Schuetz, Anna Pia Plazzo, Barbara Franke, Truong San Phan, Jennifer Fleming, Olga Mayans, Thomas Brunner
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:Cell Reports
Fag:
CP: Immunology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124723015255
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