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Pleural Resident Macrophages and Pleural IRA B Cells Promote Efficient Immunity Against Pneumonia by Inducing Early Pleural Space Inflammation

Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune cell compartment during bacterial pneumonia resulted in a reduced pulmonary i...

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Main Authors: Alan Bénard, Malgorzata J. Podolska, Franziska Czubayko, Isabella Kutschick, Bettina Klösch, Anne Jacobsen, Elisabeth Naschberger, Maximilian Brunner, Christian Krautz, Denis I. Trufa, Horia Sirbu, Roland Lang, Robert Grützmann, Georg F. Weber
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
pleural resident macrophages
IRA B cells
necroptosis
mincle
pleural space
bacterial airway infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.821480/full
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