Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo

In humans and other primates, red blood cells (RBCs) constitutively express high levels of liver-type arginase 1 (Arg1), which regulates systemic l-arginine and nitric oxide (NO) bioavailability, particularly under pathological conditions such as sickle cell disease. In contrast, the role of RBC Arg...

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Detalhes bibliográficos

Principais autores:	Sophia K. Heuser, Junjie Li, Zhixin Li, Anthea LoBue, Kyle Heard, Julia Hocks, Tatsiana Suvorava, Ron-Patrick Cadeddu, Corinna Strupp, Luke Dunaway, Zhengbing Zhuge, Stacy L. Gelhaus, André Heinen, Ulrich Germing, Martin Feelisch, Mattias Carlström, Brant Isakson, Malte Kelm, Jon O. Lundberg, Miriam M. Cortese-Krott
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-10-01
coleção:	Redox Biology
Assuntos:	Cre/LoxP system RBC-specific Arg1 NO bioavailability Systemic l-arginine metabolism Erythroid cell differentiation Acute myocardial infarction
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231725002812
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