Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting

Abstract The reduction in plasma leptin levels is crucial for the brain to perceive negative energy balance and activate adaptive responses, including activating corticotrophin-releasing factor neurons in the paraventricular nucleus of the hypothalamus (CRFPVN). Notably, leptin receptor (Lepr) expre...

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Principais autores:	Nathalia Lopes Ferreira, Higor J. Fideles, Ana Beatriz Marcal, Ana Paula Brianezi, João Victor Silva Nani, André Souza Mecawi, Rodrigo Rorato
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-07-01
Series:	Scientific Reports
Assuntos:	HPA axis POMC Lepr Fasting Cre-LoxP DREADDs
Acceso en liña:	https://doi.org/10.1038/s41598-025-09990-0
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