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Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery

A thermosensitive, mucoadhesive in-situ gel for clonazepam (CLZ) intranasal delivery was developed, which aimed to achieve prolonged in-situ residence and controlled drug release, overcoming problems associated with its oral or parenteral administration. Poloxamer was selected as a thermosensitive p...

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Main Authors: Marzia Cirri, Francesca Maestrelli, Giulia Nerli, Natascia Mennini, Mario D’Ambrosio, Cristina Luceri, Paola Angela Mura
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
clonazepam
in situ nasal gel
poloxamer
mucoadhesive polymers
randomly methylated β-Cyclodextrin
permeability
Online Access:https://www.mdpi.com/1999-4923/13/7/969
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