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Fragment-based discovery of novel small molecule targeting human BAG3

Bcl-2-associated athanogene 3 (BAG3) is a multifunctional co-chaperone protein that regulates apoptosis, autophagy, and proteostasis through interactions with HSP70 and other partners. Overexpression of BAG3 contributes to tumor cell survival, metastasis, and chemotherapy resistance, making it an ap...

Celý popis

Uloženo v:
Hlavní autoři: Annagiulia Favaro, Chiara Marchioro, Martina Canton, Thomas Stella, Romeo Romagnoli, Elena Mariotto, Mattia Sturlese, Giampietro Viola
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-04-01
Edice:European Journal of Medicinal Chemistry Reports
Témata:
Fragment-based drug discovery (FBDD)
BAG3 protein
Protein–protein interactions (PPIs)
Intrinsically disordered proteins (IDPs)
Small-molecule inhibitors
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2772417426000063
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