NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.

<h4>Background</h4>Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone, and osteoblasts, which build bone. Disproportionate action of OCs is responsible for the bone loss associated with postmenopausal osteoporosis and rheumatoid arthritis. NF-κB indu...

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Auteurs principaux:	Chang Yang, Kathleen McCoy, Jennifer L Davis, Marc Schmidt-Supprian, Yoshiteru Sasaki, Roberta Faccio, Deborah Veis Novack
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2010-11-01
Collection:	PLoS ONE
Accès en ligne:	https://doi.org/10.1371/journal.pone.0015383
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