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3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, including in cancer metastasis and chronic inflammation. Preclinical and recent clinical studies have now demonstrated therapeutic utility for several anti-lymphangiogenic agents...

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Principais autores: Kazuhide S. Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I. Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S. Crosier, Katarzyna Koltowska, Jonathan W. Astin, Pei Jean Tan, Benjamin M. Hogan, Vyomesh Patel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-06-01
Serier:Pharmaceuticals
Fag:
3,4-Difluorobenzocurcumin
zebrafish
lymphatic
Vegfc
Vegfr3
Erk
Online adgang:https://www.mdpi.com/1424-8247/14/7/614
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