ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Abstract Background Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. Herein, we refine the oncogenic role of ERRα in the pyroptos...

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मुख्य लेखकों:	Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	BMC 2023-10-01
श्रृंखला:	Journal of Experimental & Clinical Cancer Research
विषय:	Endometrial cancer Pyroptosis Metabolic reprogramming ERRα Cisplatin resistance
ऑनलाइन पहुंच:	https://doi.org/10.1186/s13046-023-02834-7
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