ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Abstract Background Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. Herein, we refine the oncogenic role of ERRα in the pyroptos...

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Detalhes bibliográficos

Principais autores:	Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Endometrial cancer Pyroptosis Metabolic reprogramming ERRα Cisplatin resistance
Acesso em linha:	https://doi.org/10.1186/s13046-023-02834-7
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