Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

Summary: Organoid technology provides the possibility of culturing patient-derived colon tissue and colorectal cancers (CRCs) while maintaining all functional and phenotypic characteristics. Labeling stem cells, especially in normal and benign tumor organoids of human colon, is challenging and there...

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Hauptverfasser:	Koen C. Oost, Lisa van Voorthuijsen, Arianna Fumagalli, Rik G.H. Lindeboom, Joep Sprangers, Manja Omerzu, Maria J. Rodriguez-Colman, Maria C. Heinz, Ingrid Verlaan-Klink, Madelon M. Maurice, Boudewijn M.T. Burgering, Jacco van Rheenen, Michiel Vermeulen, Hugo J.G. Snippert
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2018-02-01
Schriftenreihe:	Cell Reports
Schlagworte:	organoids intestine colorectal cancer stem cells LGR5 ASCL2
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124718300652
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