Efficacy of convection enhanced delivery of MTX110 (soluble panobinostat) in preclinical Diffuse Intrinsic Pontine Glioma models using metabolic hyperpolarized 13C imaging

Background: Diffuse intrinsic pontine glioma (DIPG) usually occurs in children and has poor outcomes despite treatment. Large drug screens have identified the pan-histone deacetylate inhibitor panobinostat as a promising agent, however clinical response might be hampered by limited blood brain barri...

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Autori principali:	Justyna M. Przystal, Ilwoo Park, Jie Zhang, Piotr Hadaczek, Krystof Bankiewicz, Nalin Gupta, Javad Nazarian, Sabine Mueller
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2023-12-01
Serie:	EJC Paediatric Oncology
Soggetti:	DIPG MTX110 Convection enhanced delivery (CED)
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2772610X23000193
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