Efficacy of convection enhanced delivery of MTX110 (soluble panobinostat) in preclinical Diffuse Intrinsic Pontine Glioma models using metabolic hyperpolarized 13C imaging

Background: Diffuse intrinsic pontine glioma (DIPG) usually occurs in children and has poor outcomes despite treatment. Large drug screens have identified the pan-histone deacetylate inhibitor panobinostat as a promising agent, however clinical response might be hampered by limited blood brain barri...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Justyna M. Przystal, Ilwoo Park, Jie Zhang, Piotr Hadaczek, Krystof Bankiewicz, Nalin Gupta, Javad Nazarian, Sabine Mueller
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2023-12-01
Saila:	EJC Paediatric Oncology
Gaiak:	DIPG MTX110 Convection enhanced delivery (CED)
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2772610X23000193
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!