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Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable

Abstract Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to boost circulating neutrophil counts. Stea...

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Principais autores: Claire A. Naveh, Kiran Roberts, Przemysław Zakrzewski, Christopher M. Rice, Fernando M. Ponce-Garcia, Kathryn Fleming, Megan Thompson, Nawamin Panyapiean, Huan Jiang, Stephanie Diezmann, Pedro L. Moura, Ashley M. Toye, Borko Amulic
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-05-01
Series:Journal of Translational Medicine
Assuntos:
Neutrophil
Granulopoiesis
Ex vivo differentiation
CD34+stem cells
Proteomics
Acceso en liña:https://doi.org/10.1186/s12967-024-05337-x
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