Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules

Summary: Neutrophils are essential immune cells loaded with cytosolic granules that contain potent antimicrobial and immunostimulatory molecules. Alterations of neutrophil granule contents are associated with immunodeficiency and hyperinflammation. Identification of regulators of granule development...

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Autori principali:	Kathryn Fleming, Kate Burley, Fernando Ponce-Garcia, Parsa Akbari, Claire Naveh, Chris Rice, Przemysław Zakrzewski, Willem Gibbs, Sarah Groves, Drinalda Cela, Venizelos Papayannopoulos, Christopher J. Harbort, Andrew Mumford, Borko Amulic
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-08-01
Serie:	iScience
Soggetti:	Biological sciences Genetics Immunology Natural sciences
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004225013331
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