Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene

DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses, mostly when present in cells in a non-replicative state with low copy numbers. However, the sheer amount of viral DNA produced within a very shor...

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書誌詳細

主要な著者:	Zrinka Didara, Florian Reithofer, Karina Zöttl, Alexander Jürets, Izabella Kiss, Angela Witte, Reinhard Klein
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-06-01
シリーズ:	Molecular Therapy: Nucleic Acids
主題:	MT: RNA/DNA editing CRISPR-Cas9 adenovirus infection virus therapy
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2162253123000537
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