Ectopic Expression of Rv0023 Mediates Isoniazid/Ethionamide Tolerance via Altering NADH/NAD+ Levels in Mycobacterium smegmatis

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) accounts for nearly 1.2 million deaths per annum worldwide. Due to the emergence of multidrug-resistant (MDR) Mtb strains, TB, a curable and avertable disease, remains one of the leading causes of morbidity and mortality. Isoniazid (INH) i...

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Principais autores:	Shailesh Kumar Gupta, Rajendra Kumar Angara, Suhail Yousuf, Chilakala Gangi Reddy, Akash Ranjan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-02-01
coleção:	Frontiers in Microbiology
Assuntos:	XRE family of protein whiB5 isoniazid resistance ethionamide resistance transcription regulation
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fmicb.2020.00003/full
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