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Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase

Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be expected to be promising drugs to fight trime...

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Hlavní autor: Pedro J. Silva
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2022-06-01
Edice:Antibiotics
Témata:
computer-aided molecular design
molecular dynamics
density-functional theory
molecular docking
drug development
On-line přístup:https://www.mdpi.com/2079-6382/11/6/779
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