Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be expected to be promising drugs to fight trime...
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| Natura: | Artigo |
| Lingua: | Inglês |
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MDPI AG
2022-06-01
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| Serie: | Antibiotics |
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| Accesso online: | https://www.mdpi.com/2079-6382/11/6/779 |
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