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Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA

Abstract Lipid nanoparticles (LNPs) are currently the most commonly used non-viral gene delivery system. Their physiochemical attributes, encompassing size, charge and surface modifications, significantly affect their behaviors both in vivo and in vitro. Nevertheless, the effects of these properties...

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Principais autores: Weiwen Kong, Yuning Wei, Zirong Dong, Wenjuan Liu, Jiaxin Zhao, Yan Huang, Jinlong Yang, Wei Wu, Haisheng He, Jianping Qi
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-09-01
Series:Journal of Nanobiotechnology
Assuntos:
Lipid nanoparticles
Size
Surface charge
PEGylated lipids
Transfection
Distribution
Acceso en liña:https://doi.org/10.1186/s12951-024-02812-x
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