Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation

Abstract Background Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FLT3-ITD-positive AML remains unsure. Methods We detected the expression...

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Autors principals:	Dan Xu, Yishan Chen, Ying Yang, Zhao Yin, Changfen Huang, Qiang Wang, Ling Jiang, Xuejie Jiang, Changxin Yin, Qifa Liu, Guopan Yu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2022-07-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Autophagy FLT3 inhibitor Resistance Acquired mutation Bone marrow micro-environment FLT3-ITD
Accés en línia:	https://doi.org/10.1186/s12967-022-03498-1
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