A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis

Abstract Background Our study aims to investigate an intrinsic link underlying sex hormone-binding globulin (SHBG) and rheumatoid arthritis (RA), which remains inconclusive in observational settings. Methods Summary statistics were collected from the largest GWAS(s) on SHBG adjusted for BMI (SHBGadj...

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Ngā kaituhi matua:	Yuan Jiang, Qianwen Liu, Lars Alfredsson, Lars Klareskog, Ingrid Kockum, Xia Jiang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2023-08-01
Rangatū:	Human Genomics
Ngā marau:	Sex hormone-binding globulin Rheumatoid arthritis Genome-wide cross-trait analysis Mendelian randomization analysis
Urunga tuihono:	https://doi.org/10.1186/s40246-023-00528-x
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!