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Treatment completion and challenges in rolling out 12-dose weekly rifapentine plus isoniazid to prevent tuberculosis among people living with HIV and pediatric household contacts in Brazil

ABSTRACT Objective: In July of 2021, the Brazilian National Ministry of Health integrated three months of once-weekly isoniazid plus rifapentine (3HP) into the National Guidelines for Tuberculosis Control as a first-line tuberculosis preventive therapy (TPT) option for people living with HIV (PLHIV...

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Main Authors: Isadora Salles, Jamile Garcia de Oliveira, Alexandra Brito de Souza, Silvia Cohn, Renata Spener-Gomes, Solange Dourado de Andrade, Valeria Saraceni, Solange Cesar Cavalcante, Jeff Weiser, Makaita Gombe, Violet Chihota, Gavin Churchyard, Richard E Chaisson, Marcelo Cordeiro-Santos, Betina Durovni
Format: Artigo
Language:Inglês
Published: Sociedade Brasileira de Pneumologia e Tisiologia 2025-10-01
Series:Jornal Brasileiro de Pneumologia
Subjects:
Tuberculosis
Latent tuberculosis
HIV infections
Isoniazid
Rifapentine
Treatment adherence and compliance
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000400604&lng=en&tlng=en
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