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MBNL1 alternative splicing isoforms play opposing roles in cancer

MBNL1 proteins lacking exon 7 (−ex7) are antisurvival factors with tumor suppressive role that cancer cells tend to down-regulate in favor of MBNL +ex7 isoforms. The extent of and the oncogenic role played by alternative splicing (AS) in cancer are well documented. Nonetheless, only few studies have...

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Autori principali: Tommaso Tabaglio, Diana HP Low, Winnie Koon Lay Teo, Pierre Alexis Goy, Piotr Cywoniuk, Heike Wollmann, Jessica Ho, Damien Tan, Joey Aw, Andrea Pavesi, Krzysztof Sobczak, Dave Keng Boon Wee, Ernesto Guccione
Natura: Artigo
Lingua:Inglês
Pubblicazione: Life Science Alliance LLC 2018-10-01
Serie:Life Science Alliance
Accesso online:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201800157
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