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TGF-β/SMAD signaling maintains nucleus pulposus stem cell quiescence to protect against oxidative injury in intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IVDD) is characterized by progressive nucleus pulposus cell loss and extracellular matrix degradation, in which persistent oxidative stress plays a critical pathogenic role. Transplantation of nucleus pulposus–derived stem cells (NPSCs) is a prom...

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Principais autores: Qi Chen, Xiaolong Chen, Qu Yang, Xinxin Miao, Jinghong Yuan, Shuihua Ding, Rui Ding, Shenghao Cai, Bin Li, Xigao Cheng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Stem Cell Research & Therapy
Fag:
Nucleus pulposus stem cells
Quiescence
IVDD
Oxidative stress
Apoptosis
P53
Online adgang:https://doi.org/10.1186/s13287-026-05031-3
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