Sulfur-and selenium-targeting warheads: reaction-based design of electrophilic warheads for selective inhibition of enzyme

Covalent inhibitors for nucleophilic residues, particularly cysteine (Cys) and selenocysteine (Sec), have resurfaced as precision therapies for modifying disease-associated enzymes. The main advantage of covalent inhibition is its ability to form a stable covalent bond with a particular residue near...

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Principais autores:	Neha Jain, Michio Iwaoka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Chemistry
Assuntos:	covalent inhibitors in situ activated warheads low toxicity selenoenzyme sulfur and selenium selective warhead design
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fchem.2026.1768658/full
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