Sulfur-and selenium-targeting warheads: reaction-based design of electrophilic warheads for selective inhibition of enzyme
Covalent inhibitors for nucleophilic residues, particularly cysteine (Cys) and selenocysteine (Sec), have resurfaced as precision therapies for modifying disease-associated enzymes. The main advantage of covalent inhibition is its ability to form a stable covalent bond with a particular residue near...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2026-03-01
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| Seria: | Frontiers in Chemistry |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.frontiersin.org/articles/10.3389/fchem.2026.1768658/full |
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