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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis

Abstract Background Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African Americans. Despite this, African Americans are dramatically underrepresented in SSc research. Additionally, monocytes show heightened activa...

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Principais autores: Peter C. Allen, Sarah Smith, Robert C. Wilson, Jena R. Wirth, Nathan H. Wilson, DeAnna Baker Frost, Jonathan Flume, Gary S. Gilkeson, Melissa A. Cunningham, Carl D. Langefeld, Devin M. Absher, Paula S. Ramos
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-02-01
Serier:Clinical Epigenetics
Fag:
Scleroderma
Autoimmune
Black
Epigenenomic
Transcriptomic
Blood
Online adgang:https://doi.org/10.1186/s13148-023-01445-5
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